Drugs · acquisition-cost intelligence
Diphenhydramine
diphenhydramine hydrochloride· ingredient diphenhydramineAntihistamines for topical use· DIPHENHYDRAMINE HYDROCHLORIDE 50 mg/mL
What this is. Acquisition-cost intelligence for pharmacy & clinic buyers — the historical trend, generic-equivalent costs, and Part D posture. NADAC is a pharmacy acquisition cost (the national average pharmacies pay), not a retail or cash price — for consumer cash prices use GoodRx/your plan.
Acquisition benchmark · NADAC per ML
$0.93723
NADAC — pharmacy acquisition cost, not a retail/cash price
Acquisition-cost history
Weekly NADAC per ML — the trend nobody else shows. 6 weeks.
2025-12-172026-05-20
Same-ingredient options by acquisition cost
Other diphenhydramine products, cheapest acquisition cost first. Per ML — confirm strength/form equivalence before switching.
| Product | NADAC / ML | vs this |
|---|---|---|
| basic care nighttime sleep aid | $0.00798 | −$0.92930 |
| Adult Allergy Relief Dye Free | $0.01987 | −$0.91740 |
| Aller-Ben | $0.03745 | −$0.89980 |
| Benadryl Extra Strength Itch Cooling | $0.04757 | −$0.88970 |
| anti itch | $0.05810 | −$0.87910 |
| Allergy Relief | $0.06040 | −$0.87680 |
| Allergy | $0.06040 | −$0.87680 |
| Advil PM | $0.12716 | −$0.81010 |
Sources: CMS NADAC (pharmacy acquisition cost), FDA NDC + RxNorm (identity), RxClass (therapeutic class), CMS Medicare Part D formulary (coverage). Observed reference data for professional buyers — not a retail/cash price, not pricing or medical advice. Verify before purchasing or substituting.