CAI
Clinical Asset Index
by VOS Supply Group
Drugs · acquisition-cost intelligence

ESTRADIOL VAGINAL INSERTS

estradiol· ingredient estradiol· ESTRADIOL 10 ug/1; ESTRADIOL 4 ug/1; ESTRADIOL HEMIHYDRATE 10 ug/1
What this is. Acquisition-cost intelligence for pharmacy & clinic buyers — the historical trend, generic-equivalent costs, and Part D posture. NADAC is a pharmacy acquisition cost (the national average pharmacies pay), not a retail or cash price — for consumer cash prices use GoodRx/your plan.
Acquisition benchmark · NADAC per EA
$27.09
NADAC — pharmacy acquisition cost, not a retail/cash price

Acquisition-cost history

Weekly NADAC per EA — the trend nobody else shows. 7 weeks.

2025-12-172026-06-01

Same-ingredient options by acquisition cost

Other estradiol products, cheapest acquisition cost first. Per EA — confirm strength/form equivalence before switching.

ProductNADAC / EAvs this
Estradiol$0.06599−$27.03
Estradiol$0.06599−$27.03
ESTRACE$0.38605−$26.71
ABIGALE$0.69593−$26.40
Mimvey$0.70126−$26.39
DIVIGEL$1.47−$25.62
ELESTRIN$3.52−$23.57
DOTTI$7.65−$19.44

Medicare Part D coverage · CY2026

On 322 plan formularies · typical tier 4
Prior auth 0% · Step therapy 0% · Quantity limit 20% of formularies

Sources: CMS NADAC (pharmacy acquisition cost), FDA NDC + RxNorm (identity), RxClass (therapeutic class), CMS Medicare Part D formulary (coverage). Observed reference data for professional buyers — not a retail/cash price, not pricing or medical advice. Verify before purchasing or substituting.