Drugs · biggest generic savings
Biggest brand→generic savings
Where switching to the same-ingredient generic cuts the most on pharmacy acquisition cost (NADAC). Ranked by per-unit savings. Matched on same ingredient, strength & pricing unit — confirm dosage form & packaging before substituting (this is acquisition-cost intelligence, not a clinical interchangeability call).
Source: CMS NADAC · effective 2026-06-03 · methodology · drugs in shortage →
IMITREX→ sumatriptan85% offsave $391.48/ML
Denavir→ penciclovir · Nucleosides and nucleotides excl. reverse transcriptase inhibitors63% offsave $97.09/GM
ZOMIG→ Zolmitriptan · Selective serotonin (5HT1) agonists97% offsave $42.72/EA · ~$1,281.47/30-ct
Alrex→ loteprednol etabonate47% offsave $27.46/ML
Azopt→ brinzolamide · Carbonic anhydrase inhibitors71% offsave $25.00/ML
Istalol→ timolol maleate · Beta blocking agents96% offsave $21.43/ML
LATISSE→ bimatoprost71% offsave $18.46/ML
Saxenda→ liraglutide18% offsave $15.48/ML
BASAGLAR KwikPen→ Rezvoglar KwikPen72% offsave $15.01/ML
Pristiq Extended-Release→ Desvenlafaxine97% offsave $13.50/EA · ~$405.09/30-ct
Timolol GFS→ Timolol Maleate · Beta blocking agents94% offsave $12.58/ML
Gralise→ gabapentin89% offsave $9.03/EA · ~$271/30-ct
FINACEA FOAM→ Azelaic Acid Gel95% offsave $7.87/GM
ConZip→ Tramadol HCL ER · Other opioids85% offsave $7.63/EA · ~$229.01/30-ct
Evoxac→ CEVIMELINE91% offsave $7.08/EA · ~$212.43/30-ct
OXTELLAR XR→ oxcarbazepine98% offsave $6.93/EA · ~$207.88/30-ct
Texacort→ hydrocortisone · Corticosteroids96% offsave $6.02/ML
AMLODIPINE, VALSARTAN, HYDROCHLOROTHIAZIDE→ OLMESARTAN MEDOXOMIL, AMLODIPINE and HYDROCHLOROTHIAZIDE · Angiotensin II receptor blockers (ARBs), plain81% offsave $5.33/EA · ~$159.79/30-ct
FABIOR→ tazarotene41% offsave $5.06/GM
Fioricet with Codeine→ Butalbital, Acetaminophen and Caffeine · Anilides94% offsave $4.94/EA · ~$148.18/30-ct
Carafate→ Sucralfate · Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD)96% offsave $4.55/EA · ~$136.48/30-ct
Anoro Ellipta→ Umeclidinium and Vilanterol Ellipta38% offsave $3.04/EA · ~$91.27/30-ct
clarithromycin→ VOQUEZNA DUAL PAK · Macrolides84% offsave $2.54/EA · ~$76.13/30-ct
ADVAIR HFA→ Fluticasone Propionate and Salmeterol HFA · Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics11% offsave $2.40/GM
adapalene→ Curist Acne Relief83% offsave $2.20/GM
Clindacin→ Clindamycin Phosphate · Antibiotics94% offsave $2.17/GM
clobetasol propionate emollient formulation→ Clobetasol Propionate · Corticosteroids, plain95% offsave $2.10/GM
lansoprazole→ Lansoprazole DR · Proton pump inhibitors95% offsave $1.96/EA · ~$58.89/30-ct
KAPSPARGO→ Metoprolol Succinate95% offsave $1.81/EA · ~$54.25/30-ct
zolmiptriptan→ Zolmitriptan · Selective serotonin (5HT1) agonists54% offsave $1.47/EA · ~$43.97/30-ct
Humulin 70/30→ Novolin N · Insulins and analogues for inhalation21% offsave $1.42/ML
Cardizem LA→ Cartia XT · Benzothiazepine derivatives88% offsave $1.39/EA · ~$41.59/30-ct
sulfacetamide sodium→ Klaron · Antiinfectives for treatment of acne71% offsave $1.33/ML
VENTOLIN HFA→ Albuterol Sulfate HFA · Selective beta-2-adrenoreceptor agonists43% offsave $1.23/GM
Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 KwikPen→ Humalog Mix75/25 · Insulins and analogues for injection, fast-acting10% offsave $1.04/ML
Humalog Mix50/50 KwikPen→ Humalog Mix75/25 · Insulins and analogues for injection, fast-acting10% offsave $0.9872/ML
Feverall Jr. Strength→ Acetaminophen 325mg · Anilides97% offsave $0.9583/EA · ~$28.75/30-ct
butalbital, acetaminophen and caffeine→ Butalbital, Acetaminophen, Caffeine and Codeine Phosphate · Other dermatologicals52% offsave $0.9057/EA · ~$27.17/30-ct
carbamazepine→ Epitol88% offsave $0.9043/EA · ~$27.13/30-ct
Feverall Infants→ Childrens Mapap · Anilides93% offsave $0.8470/EA · ~$25.41/30-ct
Methylphenidate Hydrochloride (LA)→ methylphenidate hydrochloride CD35% offsave $0.8200/EA · ~$24.6/30-ct
DERMOTIC→ DERMA-SMOOTHE/FS · Corticosteroids81% offsave $0.7841/ML
fluocinonide→ Fluocinonide Cream · Corticosteroids53% offsave $0.5435/GM
Clobetasol Propionate (emollient)→ Clobetasol Propionate · Corticosteroids, plain79% offsave $0.4684/GM
Alavert Allergy→ 24 / 7 Life Non-Drowsy Allergy Relief90% offsave $0.4617/EA · ~$13.85/30-ct
DIPROLENE→ Betamethasone Dipropionate · Corticosteroids73% offsave $0.4466/GM
clindamycin and benzoyl peroxide→ clindamycin phosphate and benzoyl peroxide · Antibiotics41% offsave $0.2879/GM
acetaminophen pain reliever fever reducer→ 8 Hour Arthritis Pain · Anilides81% offsave $0.2788/EA · ~$8.36/30-ct
Lidocaine→ Lidocaine Viscous · Amides77% offsave $0.2718/ML
Lantus→ Rezvoglar KwikPen · Insulins and analogues for injection, long-acting4% offsave $0.2404/ML
METRONIDAZOLE→ metronidazole vaginal · Antiinfectives and antiseptics for local oral treatment58% offsave $0.2069/GM
Amantadine→ Amantadine HCl · Adamantane derivatives51% offsave $0.1689/EA · ~$5.07/30-ct
Albuterol→ Albuterol Sulfate HFA · Selective beta-2-adrenoreceptor agonists9% offsave $0.1672/GM
Keppra XR→ levetiracetam · Other antiepileptics60% offsave $0.1467/EA · ~$4.4/30-ct
Metronidazole→ metronidazole vaginal · Antiinfectives and antiseptics for local oral treatment50% offsave $0.1456/GM
Fluocinonide→ Fluocinonide Cream · Corticosteroids22% offsave $0.1368/GM
Anusol HC→ Hydrocortisone · Corticosteroids56% offsave $0.1314/GM
Ascomp with Codeine→ butalbital, aspirin, and caffeine · Opium alkaloids and derivatives10% offsave $0.1090/EA · ~$3.27/30-ct
fluocinolone acetonide→ Synalar · Corticosteroids8% offsave $0.1065/GM
Insulin Glargine→ Rezvoglar KwikPen2% offsave $0.0953/ML
AMAZON BASIC CARE NICOTINE POLACRILEX→ basic care nicotine23% offsave $0.0840/EA · ~$2.52/30-ct
AMAZON BASIC CARE LOPERAMIDE HYDROCHLORIDE→ anti-diarrheal · Antipropulsives59% offsave $0.0744/EA · ~$2.23/30-ct
rizatriptan benzoate→ Rizatriptan11% offsave $0.0553/EA · ~$1.66/30-ct
KLOR-CON M→ Potassium Chloride Extended-Release · Electrolyte solutions36% offsave $0.0498/EA · ~$1.49/30-ct
Morphine Sulfate ER→ morphine sulfate · Natural opium alkaloids12% offsave $0.0440/EA · ~$1.32/30-ct
Acetaminophen, Dextromethorphan Hydrobromide, Guaifenesin, Phenylephrine Hydrochloride→ Cold Head Congestion Daytime · Adrenergic and dopaminergic agents30% offsave $0.0402/EA · ~$1.21/30-ct
Clobetasol Propionate Cream 0.05% Clobetasol Propionate Cream 0.05%→ Clobetasol Propionate · Corticosteroids, plain24% offsave $0.0379/GM
Acetaminophen 325mg, Dextromethorphan HBr 10mg and Phenyleprine Hcl 5mg→ Cold Head Congestion Daytime · Adrenergic and dopaminergic agents28% offsave $0.0369/EA · ~$1.11/30-ct
Cold and Flu Day and Night, Severe→ Allergy Multisymptom · Adrenergic and dopaminergic agents28% offsave $0.0335/EA · ~$1.01/30-ct
Best Choice Extra Strength→ Anti-Gas29% offsave $0.0292/EA · ~$0.88/30-ct
COLD AND FLU HBP→ Allergy Multisymptom · Anilides20% offsave $0.0206/EA · ~$0.62/30-ct
Depakote ER→ divalproex sodium10% offsave $0.0187/EA · ~$0.56/30-ct
LITHOBID→ Lithium Carbonate7% offsave $0.0148/EA · ~$0.44/30-ct
DOK→ basic care stool softener28% offsave $0.0107/EA · ~$0.32/30-ct
Dermavyx→ triamcinolone acetonide · Corticosteroids12% offsave $0.0103/GM
phentermine hydrochloride→ Phentermine HCL12% offsave $0.0095/EA · ~$0.28/30-ct
Pramipexole dihydrochloride→ PRAMIPEXOLE · Dopamine agonists8% offsave $0.0049/EA · ~$0.15/30-ct
Cardizem CD→ Cartia XT · Muscle relaxants2% offsave $0.0043/EA · ~$0.13/30-ct
Novolin 70/30→ Novolin N · Insulins and analogues for inhalation0% offsave $0.0037/ML
Digenyx→ Hyoscyamine Sulfate ODT2% offsave $0.0031/EA · ~$0.09/30-ct
nifedipine→ Nifedipine ER2% offsave $0.0028/EA · ~$0.08/30-ct